Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 11 0.002 0.249 0.12 0.074
biological_process el 11 0.583 0.912 0.771 0.117
biological_process ka 11 0.001 0.213 0.109 0.067
biological_process rf 11 0.002 0.249 0.12 0.074
disease ct 4 0.035 0.697 0.203 0.285
disease el 4 0.301 0.757 0.571 0.166
disease ka 4 0.004 0.656 0.173 0.279
disease rf 4 0.034 0.696 0.203 0.285
genetic_interaction ct 9 0.0 0.989 0.607 0.355
genetic_interaction el 9 0.0 0.991 0.605 0.358
genetic_interaction ka 9 0.0 0.226 0.159 0.087
genetic_interaction rf 9 0.0 0.989 0.607 0.355
molecular_function ct 2 0.43 0.636 0.533 0.103
molecular_function el 2 0.407 0.658 0.532 0.126
molecular_function ka 2 0.455 0.637 0.546 0.091
molecular_function rf 2 0.43 0.636 0.533 0.103
pathway ct 11 0.001 0.769 0.39 0.281
pathway el 11 0.0 0.759 0.312 0.286
pathway ka 11 0.0 0.181 0.024 0.05
pathway rf 11 0.0 0.637 0.281 0.227
phenotype ct 4 0.007 0.606 0.286 0.277
phenotype el 4 0.085 0.406 0.265 0.122
phenotype ka 4 0.005 0.648 0.298 0.293
phenotype rf 4 0.007 0.606 0.286 0.277
protein_interaction ct 11 0.002 0.219 0.111 0.093
protein_interaction el 11 0.002 0.174 0.071 0.067
protein_interaction ka 11 0.0 0.038 0.008 0.011
protein_interaction rf 11 0.002 0.214 0.104 0.089

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 11 0.001 0.963 0.325 0.397
integration_mean_by_presence el 11 0.0 0.797 0.232 0.288
integration_mean_by_presence ka 11 0.0 0.447 0.179 0.17
integration_mean_by_presence rf 11 0.0 0.809 0.243 0.278
mean ct 11 0.0 0.967 0.328 0.397
mean el 11 0.0 0.368 0.092 0.124
mean ka 11 0.0 0.279 0.093 0.101
mean rf 11 0.0 0.352 0.11 0.117

CDF plots of non integrated kernels

CDF plots of integrated kernels